Biological role of anti-aging protein klotho

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August undefined, 2024

WebIntroduction. Klotho, the gene encoding the antiaging protein called klotho, was discovered in 1997 when mice developed multiple organ failure and shortened life span resembling human premature aging after this gene was serendipitously silenced. 1 The klotho-deficient phenotype can be rescued by overexpressing klotho via genetic … WebApr 9, 2024 · Klotho is an anti-ageing protein that can attenuate ageing-related diseases to extend healthspan. 8, 9 α-Klotho declines with ageing in mice and humans. 10 …

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WebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney … WebMay 1, 2015 · Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the … small lounge side tables

The Biological Role of Klotho Protein in the Development of

WebKlotho is an anti-aging gene, and mutation of the mouse Klotho gene leads to premature aging syndrome [35]. Klotho protein is expressed predominantly in the kidneys. The expression of Klotho is decreased in the kidneys of not only rat models such as hypertensive rats, {5/6}-nephrectomized rats, and diabetic rats, but also in patients with … WebOct 20, 2024 · Klotho is an anti-aging protein with several therapeutic roles in the pathophysiology of different organs, such as the skeletal muscle and kidneys. Available evidence suggests that exercise ... WebFormer member of the Abraham Lab at Boston University School of Medicine investigating the anti-aging protein, Klotho, and its role in … highland league football scores

Biological Role of Anti-aging Protein Klotho - PubMed

WebMar 30, 2015 · Search worldwide, life-sciences literature Search. Advanced Search WebNov 19, 2013 · The Klotho gene was identified as an ‘aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early death. Both the membrane and secreted forms of Klotho have biological activity that include regulatory effects on general metabolism and a more specific effect … highland journey scotch priceWebThe long non-coding RNAs (lncRNA) play an important role in several biological processes including some renal diseases. Nevertheless, little is known on lncRNA that are expressed in healthy kidney and involved in renal cell homeostasis and development, and even less is known about lncRNA involved in the maintenance of human adult renal stem/progenitor … small love notes for wife

"WebFeb 1, 2024 · The α-Klotho gene is located on human chromosome 13 and contains five exons [1, 2] and encodes a single-pass type I transmembrane protein with three domains: a short intracellular domain (~60 amino acids), a transmembrane domain, and a large extracellular domain (~950 amino acids).As an anti-aging protein, α-Klotho is widely … " - Biological role of anti-aging protein klotho

Biological role of anti-aging protein klotho

Could α-Klotho Unlock the Key Between Depression and

WebDec 9, 2024 · Biological Role of Anti-Aging Protein Klotho. Klotho is an anti-aging protein that is mostly detected in the kidney and brain. It was first identified in mice as … WebKlotho plays a major role in kidney disease as much of the Klotho protein circulating in the blood is produced in the kidneys. ... Aging is a complex biological process regulated by multiple intrinsic and extrinsic factors such as genetics, epigenetics, environment, lifestyle, and immune response. Aging is often defined as an age-related ...

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WebKlotho is an anti-aging transmembrane protein, which can be shed and can function as a hormone. Accumulating data indicate that klotho is a tumor suppressor in a wide array … WebSleep and Klotho have both been closely related to the ageing process, both playing a substantial role in the endocrine and immune systems and, thereby, in oxidative stress and chronic inflammation. However, there are no studies elucidating the relationship between sleep and Klotho. Therefore, this study investigated the association of sleep quantity …

WebApr 12, 2024 · Previously, we found that an anti-aging protein β-Klotho could significantly improve the proliferation of healthy and diabetic human ADSCs [32]. Most studies … WebKlotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression molecule. ... Kałużna-Oleksy …

WebApr 10, 2024 · NANOG (Part 1): Its Role In Aging And Cancer. This is the first article in a series on the NANOG protein. Please see my companion series on klotho, another … WebJul 30, 2024 · Klotho is highly expressed in the brain. Many studies have demonstrated a neuroprotective role of Klotho. In the human brain, the secreted isoform of the Klotho …

Web2012). The systemic effects of Klotho protein appear to be primarily due to its circulating form of secreted soluble Klotho protein, which operates as a humoral factor (Chang et …

WebAug 29, 2014 · Generation of reactive oxygen species (ROS), leading to oxidative damage and neuronal cell death, plays an important role in the pathogenesis of neurodegenerative disorders, including Alzheimer disease. The present study aimed to examine the mechanism by which the anti-aging protein Klotho exerts ne … highland house apartments chevy chase mdWeb2012). The systemic effects of Klotho protein appear to be primarily due to its circulating form of secreted soluble Klotho protein, which operates as a humoral factor (Chang et al. 2005) – potentially through bind-ing to its putative, yet still unknown, cell-surface receptor – and as an enzyme regulating the biological small loveseat beach chairWebKlotho is an aging suppressor protein that is abundant in kidney tissue and Klotho-knockout mice have been shown to develop a syndrome similar to premature aging (30,31). The present study focused on determining the relevance of radiation-induced cellular senescence and the involvement of Klotho. highland lodge beddingWebThe main spot of Klotho activity is kidney and in the physiological state presumably the most important one. 6 This idea is warranted by the study made on mice with a kidney-specific ablation of Klotho which demonstrated the phenotype of global Klotho knockout mice. 21 The serum soluble Klotho was declined about 80% in those kidney-specific ... highland humane society sebring flWebThe Klotho gene was identified as an 'aging suppressor' in mice. Overexpression of the Klotho gene extends lifespan and defective Klotho results in rapid aging and early … highland malt case study solution pdfWebDec 1, 2024 · Klotho, an anti-aging protein (soluble or membrane-bound) plays a prominent role in understanding the aging process. It exerts various protective activities for neurons and multiple organs. Klotho ... small lounge reclinersWebMar 30, 2015 · Biological Role of Anti-aging Protein Klotho Abstract. Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice … highland london