Cisplatin discovery

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August undefined, 2024

WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, … WebApr 14, 2024 · In order to find the most significant changes between ABs induced by cisplatin and ABs induced by UV light, partial least squares-discriminant analyses (PLS-DA) were performed for both sequences. Unlike PCA, PLS-DA is a supervised multivariate analysis that relies on the class membership of each observation.

Current FDA-approved treatments for non-small cell lung …

WebApr 13, 2024 · According to investigations, CAFs promote the survival of HPV-negative HNSCC after cisplatin treatment [7, 113], as well as HPV-positive and negative cells that receive cetuximab [114, 115] and ... The compound cis-[Pt(NH3)2Cl2] was first described by Italian chemist Michele Peyrone in 1845, and known for a long time as Peyrone's salt. The structure was deduced by Alfred Werner in 1893. In 1965, Barnett Rosenberg, Van Camp et al. of Michigan State University discovered that electrolysis of platinum electrodes generated a soluble platinum complex which inhibited binary fission in Escherichia coli (E. coli) bacteria. Although bacterial cell growth continued, cell division … botao trava g5

Special Issue "Metabolomics in Drug Discovery and Development"

WebMay 1, 2006 · Cisplatin is currently one of the most widely used anticancer drugs in the world. The unlikely events surrounding the discovery of its anticancer activity, … WebApr 11, 2024 · Founded in December 2012, Junshi Biosciences (HKEX: 1877; SSE: 688180) is an innovation-driven biopharmaceutical company dedicated to the discovery, development, and commercialization of ... botao tracao s10 2013

Heterogeneity of cancer-associated fibroblasts in head and neck ...

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WebThe story of the invention of the anticancer drug cisplatin is a story of chemistry hidden in the science of biology. A group of researchers at Michigan State University subsequently found that cisplatin could also be used to inhibit the growth of cancer cells. WebNov 23, 2024 · Since its discovery, cisplatin has become the key drug in chemotherapy for cancers. Nevertheless, chemoresistance in cancers has become an impediment in using cisplatin for cancer treatment. The resistance toward cisplatin is multifaceted as it involves multiple cellular pathways. Ever since the knowledge of long noncoding RNAs as … botao tracao s10 2014WebCisplatin 9. The Discovery - One Scientist's Story ChemCases Kennesaw State University References As we saw in the role of platinum electrodes module, the researchers found … botao vidro gol g1

"WebSep 15, 2024 · Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance. Dinuclear Pd(II) complexes with biogenic polyamines such as spermine (Pd 2 Spm) have exhibited particularly beneficial cytotoxic properties, hence ... " - Cisplatin discovery

Cisplatin discovery

GSDMD enhances cisplatin-induced apoptosis by promoting the …

WebApr 20, 2024 · Incidentally, cisplatin was discovered by a young creative scientist, Barnett Rosenberg, who claimed that he had “no competence in biology”. The story of this … WebSep 18, 2024 · National Center for Biotechnology Information

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WebNational Center for Biotechnology Information WebCisplatin-based chemotherapy is the standard of care for patients with muscle-invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, although molecular determinants of cisplatin response are incompletely understood.

WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebThe accidental discovery of the anticancer properties of cisplatin and its clinical introduction in the 1970s represent a major landmark in the history of successful anticancer drugs. Although carboplatin--a second-generation analogue that is safer but shows a similar spectrum of activity to cisplat …

WebThe initial discovery was quite serendipitous. Rosenberg was looking into the effects of an electric field on the growth of bacteria . He noticed that bacteria ceased to divide when … WebThe initial discovery was quite serendipitous. Rosenberg was looking into the effects of an electric field on the growth of bacteria. He noticed that bacteria ceased to divide when placed in an electric field and eventually traced the cause of this phenomenon to the platinum electrode he was using. [2]

WebApr 5, 2024 · The discovery of cisplatin is truly a journey of serendipity. In 1965, Rosenberg and his colleagues noticed that when the bacteria Escherichia coli was incubated in an ammonium chloride growth medium inside a chamber with platinum electrodes, they exhibited an unusual growth limiting and filamentation behavior [].The chemical …

WebThe Italian chemist Michele Peyrone (1813–1883) was the first to synthesise cisplatin (cis-diamminedichloroplatinum (II)), the basis of today's most widely used family of anticancer … botao update btvWebJan 1, 1980 · INTRODUCTION. Cisplatin ( cis -dichlorodiammineplatinum II) is the first member of a new class of potent anticancer drugs, the metal coordination complexes, to enter general use in cancer chemotherapy. This represents a reintroduction into medicine of such metal complexes in recent times. botao trava portaWebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral membrane of proximal tubules and mediates the transport of cisplatin from the blood to proximal tubule cells. botao trava vidro gol g5WebOct 30, 2024 · This study shows that cisplatin resistance can occur by a non-genetic mechanism in the TME in which CAFs regulate thiol metabolism, thereby impairing … botao trava c3WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … botao vidro gol g5WebMar 29, 2024 · The team’s studies found that efficacy of the anticancer drug cisplatin was increased when treatment was combined with the antifibrotic drug nintedanib. Addition of nintedanib improved cisplatin ... botao uploadWebCisplatin and derivatives have been one of the most successful therapies in spite of their side effects and low specificity. Some of the drugs developed after cisplatin discovery, have been targeted the epidermal growth factor receptor, anaplastic lymphoma kinase, programmed cell death 1 ligand and … botao uva