Cisplatin toxicity prevention

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August undefined, 2024

WebAug 22, 2015 · The standard approach for prevention of CIN is the administration of lower doses of cisplatin in combination with full intravenous hydration prior and after cisplatin administration. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds. WebCombined cisplatin, ifosfamide and bleomycin (PIB) chemotherapy was given to 14 (11 recurrent and 3 advanced and metastatic) cervical carcinoma patients. At least 2 cycles of chemotherapy were given before assessment of tumour response. The overall response rate was 28.6%; the complete response rate …

Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity

WebReductions in antioxidant capacity with respect to corresponding controls were also restored by OLE treatment. These findings suggest that the OLE treatment against cisplatin-induced toxicity improves the function of blood cells and helps them to survive in the belligerent environment created by free radicals. WebFeb 22, 2024 · Cisplatin is a known nephrotoxic agent, so reducing its concentration to get a similar toxicity profile in NSCLC cells is advantageous. For the two normal lung cell lines ( Figure 4 A,B), while the Lipo-PEITC-CDDP caused the lowest survival percentages, 59.0 ± 15.7% and 71.5 ± 11.0% for WI-38 and BEAS-2B, respectively, the cytotoxic effect of ... small wood shed with porch

Clinical comparative investigation of efficacy and toxicity of ...

WebStrategies to prevent cisplatin ototoxicity have utilized antioxidants, transport inhibitors, G-protein receptor agonists, and anti-inflammatory agents. There are no FDA-approved drugs to prevent cisplatin ototoxicity. It is critical that potential protective agents do not interfere with the antitumor efficacy of cisplatin. WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. … WebThis regimen must be administered by a clinician trained in the use of chemotherapy, who should use independent medical judgment in the context of individual circumstances to make adjustments, as necessary. IV: intravenous; CBC: complete blood count; GFR: glomerular filtration rate. hikvision machine vision camera sdk

Bleomycin etoposide and cisplatin regimen - UpToDate

Cisplatin: a review of toxicities and therapeutic applications

WebAbstract Purpose: Cisplatin (CP)-induced nephrotoxicity is associated with the increased generation of reactive oxygen metabolites and lipid peroxidation in kidney, caused by the decreased levels of antioxidants and antioxidant enzymes. WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinomas, germ cell tumors, lymphomas, and … small wood shelfWebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of … small wood sheets

"WebThe principle of action of Cisplatin in combating cancer involves exerting its cytotoxicity upon cancer cells through the formation of DNA adducts that include mono-, inter, and intrastrand cisplatin DNA cross-links that arrest the cell cycle at S, G1 or G2-M thus induces apoptosis. " - Cisplatin toxicity prevention

Cisplatin toxicity prevention

FDA approves sodium thiosulfate to reduce the risk of …

WebFeb 11, 2024 · Forty-four percent of patients developed cisplatin-regimen toxicity: 15% developed cisplatin-induced nephrotoxicity, 9% cisplatin-induced ototoxicity and 27% … WebChemotherapy is one of the most important treatment methods, especially for advanced NSCLC. 3 We conducted clinical retrospective observational analyses to observe the curative effect and toxicity of cisplatin in combination with gemcitabine or Abraxane as first-line chemotherapy for stage III/IV NSCLC. Patients and methods. Clinical data

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WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebSep 20, 2024 · Patients were randomized (1:1) to receive cisplatin-based chemotherapy with or without sodium thiosulfate administered at various doses of 10 g/m2, 15 g/m2, or …

WebAdverse effects of RT-CT were grades 3 to 4 neutropenia (four patients) and grade 3 esophageal toxicity (one patient). No treatment-related deaths occurred. Conclusion: The oral vinorelbine-cisplatin combination with concurrent RT is feasible and has a favorable risk-benefit ratio in stage IIIA/IIIB NSCLC. WebApr 12, 2024 · Currently, gemcitabine/cisplatin is first-line therapy for advanced iCCA based on the ABC-02 clinical trial (ClinicalTrials.gov identifier NCT02170090). That phase 3 study included 410 patients with locally advanced or metastatic CCA, gallbladder cancer, or ampullary cancer.

WebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival. WebJun 13, 2024 · A better understanding of the mechanisms by which cisplatin causes oxidative stress and toxicities will also stimulate the development of specific inhibitors that could prevent or ameliorate cisplatin-induced nephrotoxicity and hepatotoxicity [ 68 ].

WebNov 26, 2024 · It is mainly focused on four drugs: Cisplatin, Methotrexate, Doxorubicin, and Bleomycin. (3) Results: In experimental models and the few existing clinical studies, modulation of free radicals and antioxidants by ozone therapy was associated with decreased chemotherapy-induced toxicity.

WebMay 18, 2024 · Dose-related renal toxicity is a dose-limiting side effect of cisplatin. Renal toxicity is one of the main causes of treatment discontinuations, accounting for 25–30% … hikvision machine visionWebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast … small wood sheds for sale wichita ksWebSep 3, 1991 · After a preliminary dose-finding study involving 12 patients with advanced or locally recurrent head and neck cancer, 27 patients were treated on a phase II protocol, using fluorouracil 350 mg/m2/d by continuous intravenous (IV) infusion over 5 days, followed on the sixth day by a 2-hour IV infusion … small wood sheds with windows for saleWebChemotherapy is one of the most important treatment methods, especially for advanced NSCLC. 3 We conducted clinical retrospective observational analyses to observe the … small wood shelf amazonWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. hikvision magnetic door contactWebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against … hikvision machine vision cameraWebDec 1, 2024 · Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis. and scavenge free radicals in the liver after cisplatin administration. hikvision malware