WebFor the latest local health and care information, visit the new websites for Integrated Care Board hertsandwestessex.icb.nhs.uk or the Integrated Care System hertsandwestessexics.org.uk. From 1 July 2024, Clinical Commissioning Groups will be cease to exist. Commissioning functions and information that has been previously held … WebIndications and Dosage. Adult: For treatment following 5-10 days of initial therapy with parenteral anticoagulant, and for prophylaxis of recurrent cases: ≤60 kg: 30 mg once daily; >60 kg: 60 mg once daily. Duration of treatment is individualised based on assessment of treatment benefits against the risk for bleeding.
Dabigatran, Rivaroxaban, Edoxaban and Apixaban for AF
WebEdoxaban Renal function. Take action if creatinine clearance abnormal: CrCL less than 15mL/min: edoxaban is contraindicated. Assess for bleeding or anaemia and seek advice regarding alternative anticoagulant therapy. CrCL 15-50mL/min: reduce dose to 30mg once daily. CrCL over 80mL/min: re-evaluate treatment choice and consider alternative. WebDabigatran contraindicated. Apixaban, rivaroxaban and edoxaban – lower doses have been approved for patients with CrCl 15 - 30 mL/min. Apixaban is the least renally cleared and recommended by NICE for chronic kidney disease (CKD) patients. Moderate renal impairment (CrCl 30 - 50 mL/min) Apixaban Rivaroxaban 15 mg Edoxaban 30 mg marcel massini report
Guidance on Converting Between Anticoagulants
WebRefer to Persistent Atrial Fibrillation guideline for guidance on edoxaban dosing and dose adjustment. Switching from warfarin to edoxaban: discontinue warfarin and start edoxaban when INR is ≤2.5. Venous thrombosis (first or recurrent event): Refer to Diagnosis and Treatment of Venous Thromboembolism guideline for full information. WebEdoxaban is a direct and reversible inhibitor of activated factor X (factor Xa), which prevents conversion of prothrombin to thrombin and prolongs clotting time, thereby reducing the … WebOct 23, 2024 · Edoxaban is prescribed to treat blood clots causing deep vein thrombosis and pulmonary embolism. You may also be prescribed edoxaban to help protect against … marcel merritt