Htra protease family as therapeutic targets

Author: gdhi

August undefined, 2024

WebThe HtrA proteases degrade damaged proteins and thus control the quality of proteins and protect cells against the consequences of various stresses; they also recognize specific protein substrates and in this way participate in regulation of many pathways.

Over-activation of a nonessential bacterial protease DegP as an ...

WebUntitled - Free download as PDF File (.pdf), Text File (.txt) or read online for free. WebDifferent types of granular corneal dystrophy (GCD) and lattice corneal dystrophy (LCD) are associated with mutations in the transforming growth factor beta induced gene … meaning of tuesday

Bacterial serine protease HtrA as a promising new target for ...

WebHtrA is responsible for disrupting the lateral junctions between epithelial cells. The mechanism by which C. jejuni opens tight junctions is yet unknown. For both pathogens, an HtrA-mediated transmigration process was observed [20, 21, 28], enabling bacterial contact with Fig. 1 Domain structure of HtrA proteins in Gram-negative bacteria. http://mail.eurekaselect.com/article/48054 Web1 jul. 2010 · The HtrA family proteins are serine proteases that are involved in important physiological processes, including maintenance of mitochondrial homeostasis, apoptosis … meaning of tues

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Upregulation of HTRA1 mediated by the lncRNA NEAT1/miR-141 …

Web1 jul. 2010 · The HtrA family proteins are serine proteases that are involved in important physiological processes, including maintenance of mitochondrial homeostasis, apoptosis … Web18 sep. 2012 · HtrA1 is a member of HtrA family proteins that are distributed in a range of species from bacteria, yeast, and plants to humans. 7, 9 Bacterial HtrAs are heat shock … meaning of tuesday bornWeb20 sep. 2024 · Summing up, our results provide new insight into the mechanism of the human HtrA4 protease action in cell death and oncogenesis. Since HtrA4 stimulates … meaning of tuesday\u0027s gone

"WebThis protease belongs to the S16 family of LonA proteases (Gottesman et al., 1978 and Charrette et ... or in a targeted manner by transfection, transduction, natural transformation or electroporation (Bron et al ... (Delorme et al., 2010). In contrast, the two proteases HtrA and STER_1612 are present in all strains, and their protein ... " - Htra protease family as therapeutic targets

Htra protease family as therapeutic targets

Web21 mei 2024 · Abstract. High-temperature requirement protease A4 (HtrA4) is a secretary serine protease whose expression is up-regulated in pre-eclampsia (PE) and hence is a possible biomarker of PE. It has also been altered in cancers such as glioblastoma, breast carcinoma, and prostate cancer making it an emerging therapeutic target. Among the … Web18 mei 2010 · Expert opinion on therapeutic targets (2010-05-18) Dorota Zurawa-Janicka, Joanna Skorko-Glonek, Barbara Lipinska. PMID 20469960. ABSTRACT. The HtrA …

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Web5 apr. 2024 · DOI: 10.1007/s11626-023-00760-8 Corpus ID: 257953735; Upregulation of HTRA1 mediated by the lncRNA NEAT1/miR-141-3p axis contributes to endometriosis development through activating NLRP3 inflammasome-mediated pyroptotic cell death and cellular inflammation. Web9 dec. 2024 · Anti-Infective Agents HtrA Protease Family as Therapeutic Targets Current Pharmaceutical Design Novel Antimicrobial Agents Against Multi-drug-resistant Gram-positive Bacteria: An Overview Recent Patents on Anti-Infective Drug Discovery Management of Asymptomatic Severe Aortic Stenosis

Web15 dec. 2011 · Introduction. HtrA 1 proteins belong to a unique family of oligomeric serine proteases (S1, chymotrypsin family) that are conserved from prokaryotes to humans. DegP or HtrA is the first one in the family to be identified in Escherichia coli [1] which has a dual temperature dependent chaperone-protease activity and is active in the periplasm of the … Web14 mei 2010 · An increase in the HtrAs' proteolytic activity could be beneficial in cancer treatment, by stimulation of apoptosis, anoikis or necrosis of cancer cells, or by …

Web16 sep. 2024 · HtrA1 is a member of HtrA family proteins that are distributed in a range of species from bacteria, yeast, and plants to humans. 7,9 Bacterial HtrAs are heat shock … Web25 sep. 2024 · High-temperature requirement A (HtrA) family members are homo-oligomeric serine proteases with a high degree of conservation that participate in diverse mammalian cell processes, ... Shridhar V, et al. HtrA serine proteases as potential therapeutic targets in cancer. Curr Cancer Drug Targets. 2009;9(4):451–68.

Web8 dec. 2024 · HtrA2 expression was a predictor for sensitivity to chemotherapy, and could be a candidate of molecular target in the treatment of high-grade serous ovarian cancers. results suggest that in some families, HTRA2 p.G399S is responsible for hereditary essential tremor and that homozygotes for this allele develop Parkinson disease

WebThe HtrA proteases degrade damaged proteins and thus control the quality of proteins and protect cells against the consequences of various stresses; they newsletter banner … pedja ford suboticaWeb24 apr. 2024 · Lymphedema (LE) affects millions of people worldwide. It is a chronic progressive disease with massive development of fibrosclerosis when untreated. There is no pharmacological treatment of lymphedema. The disease is associated with swelling of the interstitium of the affected organ, mostly arm or leg, impressive development of adipose … pedkey.txtWeb1 jan. 2013 · Search life-sciences literature (Over 39 million articles, preprints and more) meaning of tuesday afternoon songWebThus, the HtrA proteases of bacterial pathogens are attractive targets for new therapeutic approaches aimed at inhibiting their proteolytic activity. The exported HtrAs are … meaning of tufiakwaWeb1 mei 2013 · The high-temperature requirement serine protease (HTRA) family constitutes a well-conserved group of proteolytic enzymes (HTRA1, 2, 3, and 4), having key roles in protein quality control as well as in the regulation of various signaling pathways through the degradation of specific substrates. 1, 2 Of the four known members, HTRA1 and -2 are … meaning of tufailWeb26 mrt. 2024 · The HtrA family of chaperones and serine proteases is important for regulating stress responses and controlling protein quality in the periplasm of bacteria. … meaning of tuesday\u0027s gone with the windWebHtrA proteases regulate cellular homeostasis and cell death. Their dysfunctions have been correlated with oncogenesis and response to therapeutic treatment. We investigated the relation between HtrA1-3 expression and clinicopathological, and survival data, as well as the microsatellite status of tumors. Sixty-five colorectal cancer patients were included in … pedja rogic buffer