Kif11 control
Web28 mei 2024 · KIF11 is a highly conserved motor protein playing crucial roles in multiple cellular functions, including mitosis, intracellular transport of vesicles and organelles, and cell migration [13, 14]. Especially during mitosis, KIF11 is essential for the separation of sister chromatids. WebOur data provide extensive evidence to demonstrate that KIF11 inhibitors showed pronounced antitumor activity, acting in key points of tumorigenesis and cancer progression in in vivo xenograft...
Kif11 control
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Web(B) Levels of KIF11 and KIF14 mRNA were measured 48 h after siRNA transfection and expressed in amount of fold-change relative to scrambled siRNA-treated controls. Web19 sep. 2024 · Notably, the KIF11 mRNA expression elevated with the increasing histological grade of CCA from the TCGA database, suggesting KIF11 expression may …
Web2 jun. 2014 · The mitotic kinesin KIF11 (also called Eg5) plays critical roles in spindle functions. ... While control SBR1 and SBR4 were resistant to SB743921-mediated G 2 /M arrest, they became sensitized to the drug after KIF15 was downregulated (Figure 6C). Web16 mei 2024 · KIF11 is an evolutionarily conserved microtubule motor protein that functions in centrosome and chromosome dynamics in mitosis. Interestingly, the yeast ortholog of …
Web23 mei 2016 · KIF11 gene mutations cause a rare autosomal dominant inheritable disease called microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR). Recently, such mutations... Web29 jan. 2024 · During mitosis, Kif11, a kinesin motor protein, promotes bipolar spindle formation and chromosome movement, and during interphase, Kif11 mediates diverse …
WebKIF11 defects leads to cancer progression, for example by increasing the development of invasion and metastasis [21]. KIF11 is broadly expressed in lymph node, bone marrow, and other normal tissues. Recent researches reported that KIF11 was overexpressed in several tumors and associated with the poor prognosis, such as prostate cancer [22], gastric
Web2 jun. 2024 · KIF11 is needed for bipolar spindle formation in metaphase. We identified KIF11 as a universal target of all ATRT-molecular-subtypes. Ispinesib, a KIF11-inhibitor, effectively inhibited tumor... echo base64 windowsWeb18 dec. 2024 · Kif11 immunostaining in the mouse retina showed localization in the retinal pigment epithelium, the inner segment, and the ciliary region of the photoreceptor layer, … compound containing goldWebKIF11, a plus end-directed kinesin, as a key gene in benzo(a)pyrene-induced non-small cell lung cancer. Five novel copy number variations detected in patients with familial … echo base 11WebOur data provide extensive evidence to demonstrate that KIF11 inhibitors showed pronounced antitumor activity, acting in key points of tumorigenesis and cancer … compound continuously meanWebAdenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.Mutations in the APC gene may result in colorectal cancer.. APC is … echo bars and chainsWeb19 sep. 2024 · I Cell sensitivity to SB743921 treatment in control and KIF11-knockdown cells. CCLP1 and TFK1 cells transfected with indicated siRNA or NC were exposed to SB743921 for 72 h. echo base64 -d bashWebIMP3 regulates CD44 and KIF11. (A) Total CD44 protein was measured in whole cell lysates 48 h after transfection. Treatment with IMP3 siRNA resulted in a significant decrease in CD44 protein... echo bar \u0026 chain oil sds